Prion protein is the protein responsible for human Creutzfeldt-Jakob Disease (CJD), and somatic mutations of the prion gene are responsible for Gerstmann-Straussler-Scheinker disease and Fatal Familial Insomnia. The bovine homolog of the prion protein is responsible for bovine Spongioform Encephalopathy (BSE), also known as “Mad Cow Disease.” In all cases, the prion protein has two folding states, with one state being the “normal” non-pathological form, and the other state inducing a spongioform encephalopathy.
Species Reactivity: Mouse, Human, Rat
Form: Mixture of IgY fraction (10 mg/ml) and affinity-purified antibodies (50 ug/ml)
Storage Temperature: -20°C
Antibody Type: Polyclonal
Conjugate Type: none
Storage Instructions: -20°C
Special Shipping Instructions: Room Temperature
Shipping Method: Overnight Priority
Chicken anti-Prion antibodies, 200 ul, 10.0 mg/ml. Recommended Dilutions: 1:1000-1:5000 Immunohistochemistry, 1:2500 Western Blot.