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    Why Use Chicken IgY?

  • Here are top 5 reasons:

    1. Higher titres against highly conserved mammalian gene products

    2. Double immunostaining is easier to perform

    3. Animal-friendly -- we purify the antibodies from eggs, not serum

    4. Large quantities of antibody - faster and cheaper

    5. Nearly unlimited quantities (again, because the antibodies come from eggs)

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How much IgY is present in chicken eggs?

The concentration of antibody in the egg yolk is somewhat higher than that found in serum. Whereas human serum typically contains 10-12 mg IgG/ml, egg yolks contain between 15-25 mg IgY/ml (Akita and Nakai, 1993). Presumably, this high concentration of antibody is used to confer passive immunity to newly hatched chicks. The rate of antibody production in laying chickens is, in fact, quite remarkable. According to Larsson et al (1993), “in 1 week a hen produces egg antibodies equivalent to 90-100 ml of serum.” This article also states that “only large mammals such as cows or horses can produce more antibodies than a laying hen.” Gassmann et al. (1990) states that “the amount of purified IgY produced in one month is 18 times higher than that of IgG produced in a rabbit.”